Autopsy report on pseudo-Bartter syndrome with renal calcification induced by diuretics and diet pills.

Abstract

A woman in her mid-forties had repeated vomiting and diarrhoea accompanied by muscle weakness soon after she started taking seven different diet pills imported from Thailand. After she had taken the pills for 8 days, respiratory depression progressed rapidly to arrest. Blood tests at the Emergency Department showed severe hypokalaemia with metabolic alkalosis. We diagnosed that she had developed pseudo-Bartter syndrome from the findings based on ionic abnormalities and high renin and aldosterone levels, and hyperplasia of the juxtaglomerular apparatus. A postmortem blood analysis indicated subtherapeutic levels of furosemide. We concluded that the patient died from pseudo-Bartter syndrome, which was triggered by chronic self-administration of furosemide and aggravated by the diet pills. This is the first pseudo-Bartter syndrome autopsy report to show histological localisation of calcification in the kidneys.

• Authors: Kana Unuma, Akihiro Tojo, Kazuki Harada, Kanju Saka, Makoto Nakajima, Takeshi Ishii, Toshiro Fujita, Ken-Ichi Yoshida
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2009 ( 2009) ISSN: 1757-790X [Electronic] England
• PMID: 21686346 (Publication Type: Journal Article)