Successful pulmonary artery embolectomy in a patient with a saddle Wilms tumor embolus.

Abstract

Denys-Drash syndrome is a genetic disorder characterized by ambiguous genitalia, cryptorchidism, nephrotic syndrome, and a high predilection for Wilms tumor with intravascular invasion. We report a 5-year-old male with Denys-Drash syndrome who rapidly developed Wilms tumor with vascular invasion, subsequent saddle tumor embolus, and required emergent embolectomy. This case illustrates the rapid emergence of Wilms tumor in a patient with Denys-Drash syndrome and the importance of considering embolectomy over thrombolytic therapy for PE in this population, given a high likelihood of tumor embolus.

• Authors: Lindsey Cooper, Colin Moore, Brian Branchford, Brian Greffe, Kelley Capocelli, Austine Kuder, Inder Mehta, Peter M Mourani
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 58 Issue 5 Pg. 806-9 (May 2012) ISSN: 1545-5017 [Electronic] United States
• PMID: 21681933 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011 Wiley Periodicals, Inc.

Topics

• Child, Preschool
• Denys-Drash Syndrome (complications)
• Embolectomy
• Humans
• Kidney Neoplasms (complications)
• Male
• Pulmonary Artery (surgery)
• Pulmonary Embolism (surgery)
• Wilms Tumor (complications)