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Antifungal activity of lariciresinol derived from Sambucus williamsii and their membrane-active mechanisms in Candida albicans.

Abstract
Lariciresinol is an enterolignan precursor isolated from the herb Sambucus williamsii, a folk medicinal plant used for its therapeutic properties. In this study, the antifungal properties and mode of action of lariciresinol were investigated. Lariciresinol displays potent antifungal properties against several human pathogenic fungal strains without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of action of lariciresinol, the membrane interactions of lariciresinol were examined. Fluorescence analysis using the membrane probe 3,3'-diethylthio-dicarbocyanine iodide (DiSC(3)-5) and 1,6-diphenyl-1,3,5-hexatriene (DPH), as well as a flow cytometric analysis with propidium iodide (PI), a membrane-impermeable dye, indicated that lariciresinol was associated with lipid bilayers and induced membrane permeabilization. Therefore, the present study suggests that lariciresinol possesses fungicidal activities by disrupting the fungal plasma membrane and therapeutic potential as a novel antifungal agent for the treatment of fungal infectious diseases in humans.
AuthorsBomi Hwang, Jaeyong Cho, In-sok Hwang, Hong-Guang Jin, Eun-Rhan Woo, Dong Gun Lee
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 410 Issue 3 Pg. 489-93 (Jul 08 2011) ISSN: 1090-2104 [Electronic] United States
PMID21679690 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Inc. All rights reserved.
Chemical References
  • Antifungal Agents
  • Benzothiazoles
  • Carbocyanines
  • Fluorescent Dyes
  • Furans
  • Hemolytic Agents
  • Lignans
  • Diphenylhexatriene
  • Propidium
  • 3,3'-dipropyl-2,2'-thiadicarbocyanine
  • lariciresinol
Topics
  • Antifungal Agents (chemistry, isolation & purification, pharmacology)
  • Benzothiazoles (chemistry)
  • Candida albicans (drug effects)
  • Carbocyanines (chemistry)
  • Cell Membrane (drug effects)
  • Cells, Cultured
  • Diphenylhexatriene (chemistry)
  • Erythrocytes (drug effects)
  • Flow Cytometry
  • Fluorescent Dyes (chemistry)
  • Furans (chemistry, isolation & purification, pharmacology)
  • Hemolysis
  • Hemolytic Agents (chemistry, isolation & purification, pharmacology)
  • Humans
  • Lignans (chemistry, isolation & purification, pharmacology)
  • Propidium (chemistry)
  • Sambucus (chemistry)

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