Use of a handheld, semiconductor (cadmium zinc telluride)-based gamma camera in navigation surgery for primary hyperparathyroidism.

Abstract

The recent development of gamma-ray probes makes it possible to perform radioguided surgery for primary hyperparathyroidism (PHPT). There have only been a few reports, however, regarding the use of a handheld gamma camera to detect parathyroid adenoma intraoperatively. The aim of this preliminary study was to assess the efficiency of a semiconductor gamma camera (eZ-SCOPE AN) in navigation surgery for PHPT. The eZ-SCOPE is designed to be used as a handheld, regional diagnostic imaging device. Eleven consecutive patients with documented primary hyperparathyroidism underwent surgery using this compact camera. Scintigraphy images of the neck by eZ-SCOPE were acquired: 1) before skin incision; 2) after adenoma location; 3) after adenoma excision; and 4) ex vivo imaging of the specimen. In scan-positive cases by preoperative Tc-MIBI, the eZ-SCOPE revealed parathyroid adenoma in all cases (100%), whereas ultrasound and CT showed a single adenoma in 63.6 and 72.7 per cent of cases, respectively. Navigation surgery for PHPT using the eZ-SCOPE permitted intraoperative identification and removal of parathyroid adenoma in all cases. Scintigraphy images of the neck by eZ-SCOPE also revealed a single adenoma even before skin incision. Our results suggest that Tc-MIBI scintigraphy with the eZ-SCOPE is useful for navigation surgery for PHPT. The eZ-SCOPE is useful for skin marking and could be easily applied for minimally invasive radioguided parathyroidectomy in scan-positive cases.

• Authors: Takaaki Fujii, Satoru Yamaguchi, Reina Yajima, Soichi Tsutsumi, Nobuyuki Uchida, Takayuki Asao, Noboru Oriuch, Hiroyuki Kuwano
• Journal: The American surgeon (Am Surg) Vol. 77 Issue 6 Pg. 690-3 (Jun 2011) ISSN: 1555-9823 [Electronic] United States
• PMID: 21679634 (Publication Type: Journal Article)

Topics

• Adenoma (diagnostic imaging, surgery)
• Aged
• Equipment Design
• Female
• Gamma Cameras
• Humans
• Hyperparathyroidism (diagnostic imaging, surgery)
• Male
• Middle Aged
• Minimally Invasive Surgical Procedures
• Neck (diagnostic imaging)
• Parathyroid Neoplasms (diagnostic imaging, surgery)
• Parathyroidectomy (methods)
• Radionuclide Imaging
• Semiconductors
• Surgery, Computer-Assisted (instrumentation)