Abstract |
Carlina acaulis (Asteraceae) has a long history of medicinal use in Europe due to its antimicrobial properties. The strong activity of Carlina oxide, themain compound of the essential oil of C. acaulis against two MRSA strains, Streptococcus pyogenes, Pseudomonas aeruginosa, Candida albicans, and C. glabrata was confirmed. A strong and selective activity against Trypanosoma brucei brucei with an IC₅₀ of 1.0 μg/mL and a SI of 446 compared to human HeLa cells was recorded. The selective toxicity of Carlina oxide makes it a promising lead compound for the development of drugs to treat African trypanosomiasis and multiresistant gram-positive bacteria.
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Authors | Florian Herrmann, Razan Hamoud, Frank Sporer, Ahmed Tahrani, Michael Wink |
Journal | Planta medica
(Planta Med)
Vol. 77
Issue 17
Pg. 1905-11
(Nov 2011)
ISSN: 1439-0221 [Electronic] Germany |
PMID | 21678234
(Publication Type: Journal Article)
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Copyright | © Georg Thieme Verlag KG Stuttgart · New York. |
Chemical References |
- Alkynes
- Furans
- Oils, Volatile
- Plant Oils
- carlina oxide
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Topics |
- Alkynes
(chemistry, isolation & purification, pharmacology)
- Asteraceae
(chemistry)
- Candida
(drug effects)
- Cell Line, Tumor
- Europe
- Furans
(chemistry, isolation & purification, pharmacology)
- Gram-Positive Bacteria
(drug effects)
- Humans
- Inhibitory Concentration 50
- Medicine, Traditional
- Microbial Sensitivity Tests
- Oils, Volatile
(chemistry, isolation & purification, pharmacology)
- Plant Oils
(chemistry, isolation & purification, pharmacology)
- Plants, Medicinal
(chemistry)
- Pseudomonas aeruginosa
(drug effects)
- Trypanosoma brucei brucei
(drug effects)
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