[Immunoelectron microscopical study on human pituitary corticotrophic adenomas].

Abstract

5 cases of pituitary adenomas associated with Cushing's disease or Nelson's syndrome were studied with electron microscopy and immunoelectron microscopy by using protein A--gold complex. Diversified ultrastructure was displayed in these tumors, among which 4 revealed presence of ACTH positive secretory granules. These granules were round or polyhedric in shape, varied in number, size and electronic density. Bundles of microfilaments could be seen in the tumor cells frequently, which were of the highest diagnostic value. There was no significant difference found in ultrastructure and immunocytochemical reaction of adenomas in Cushing's disease and Nelson's syndrome.

• Authors: X J Zhou
• Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology (Zhonghua Bing Li Xue Za Zhi) Vol. 19 Issue 2 Pg. 100-2 (Jun 1990) ISSN: 0529-5807 [Print] China
• PMID: 2167773 (Publication Type: Journal Article)

Chemical References

• Adrenocorticotropic Hormone

Topics

• Actin Cytoskeleton (ultrastructure)
• Adenoma (metabolism, ultrastructure)
• Adrenocorticotropic Hormone (metabolism)
• Cushing Syndrome (pathology)
• Humans
• Nelson Syndrome (pathology)
• Pituitary Neoplasms (metabolism, ultrastructure)