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Prognostic impact of phosphorylated mitogen-activated protein kinase expression in patients with metastatic gastric cancer.

AbstractBACKGROUND:
This study was designed to investigate the expression of phosphorylated mitogen-activated protein kinase (p-MAPK/Erk1 and Erk2) and its correlation with outcomes in patients with metastatic gastric cancer.
METHODS:
p-MAPK was detected by immunohistochemistry using monoclonal antibodies in a total of 223 formalin-fixed, paraffin-embedded samples obtained from 156 patients who received first-line chemotherapy in a phase III trial.
RESULTS:
p-MAPK was positive in 93 (59.6%) and negative in 63 (40.4%) of the 156 patients evaluated. Similar rates of p-MAPK positivity were found in primaries (53%) and metastatic lesions (61.4%). Overall survival was significantly shorter in p-MAPK-positive patients (13.7 vs. 8.5 months) in the univariate analysis. However, this prognostic value disappeared as a trend in the multivariate analysis (p = 0.1). There was a strong, positive correlation between p-MAPK and the MIB-1 proliferation index, but MIB-1 did not predict outcomes.
CONCLUSION:
p-MAPK expression could be a potential negative prognostic parameter in patients with metastatic gastric cancer treated with chemotherapy.
AuthorsAkin Atmaca, Claudia Pauligk, Kristina Steinmetz, Hans-Michael Altmannsberger, Elke Jäger, Salah-Eddin Al-Batran
JournalOncology (Oncology) Vol. 80 Issue 1-2 Pg. 130-4 ( 2011) ISSN: 1423-0232 [Electronic] Switzerland
PMID21677458 (Publication Type: Journal Article)
CopyrightCopyright © 2011 S. Karger AG, Basel.
Chemical References
  • MIB1 ligase, human
  • Ubiquitin-Protein Ligases
  • MAPK1 protein, human
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3
Topics
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Cell Line, Tumor
  • Cell Proliferation
  • Disease-Free Survival
  • Humans
  • Immunochemistry
  • Kaplan-Meier Estimate
  • Mitogen-Activated Protein Kinase 1 (metabolism)
  • Mitogen-Activated Protein Kinase 3 (metabolism)
  • Phosphorylation
  • Predictive Value of Tests
  • Prognosis
  • Proportional Hazards Models
  • Retrospective Studies
  • Stomach Neoplasms (drug therapy, metabolism, mortality)
  • Survival Rate
  • Treatment Outcome
  • Ubiquitin-Protein Ligases (metabolism)

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