Abstract | BACKGROUND: CASE PRESENTATION: In this report, we describe a patient with DC who developed pulmonary fibrosis seven years after HSCT for severe aplastic anemia, and was successfully treated with bilateral lung transplantation. We also performed a systematic literature review to understand the burden of pulmonary disease in patients with DC who did or did not receive an HSCT. Including our patient, we identified 49 DC patients with pulmonary disease (12 after HSCT and 37 without HSCT), and 509 with no reported pulmonary complications. CONCLUSION: Our current case and literature review indicate that pulmonary morbidity is one of the major contributors to poor quality of life and reduced long-term survival in DC. We suggest that lung transplantation be considered for patients with DC who develop pulmonary fibrosis with no concurrent evidence of multi-organ failure.
|
Authors | Neelam Giri, Rees Lee, Albert Faro, Charles B Huddleston, Frances V White, Blanche P Alter, Sharon A Savage |
Journal | BMC blood disorders
(BMC Blood Disord)
Vol. 11
Pg. 3
(Jun 15 2011)
ISSN: 1471-2326 [Electronic] England |
PMID | 21676225
(Publication Type: Journal Article)
|