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Topiramate as an adjunctive treatment for refractory partial epilepsy in the elderly.

Abstract
This double-blind, placebo-controlled study investigated the efficacy and tolerability of adjunctive topiramate in 86 elderly Chinese patients with refractory partial epilepsy. Patients who had at least four seizures per 4 weeks during an 8-week baseline period, despite medication with up to three standard antiepileptic drugs (AEDs), were randomly assigned to receive topiramate (n = 46) or placebo (n = 40). Topiramate dosages were titrated (target dose 200 mg/day orally) for 8 weeks and maintained at stable levels for another 12 weeks; concomitant AEDs continued at original dosages. All patients completed the study: 47.8% in the topiramate group and 7.5% on placebo reached ≥ 50% reduction in complex partial seizures. In the topiramate group, the most common adverse events were dizziness, somnolence, fatigue, headache and difficulty with memory; most events were transient and mild or moderate in severity. It was concluded that 200 mg/day topiramate was effective and well-tolerated in elderly patients with refractory partial epilepsy.
AuthorsL Zhang, J Huang, J-H Zhuang, L-Q Huang, Z-X Zhao
JournalThe Journal of international medical research (J Int Med Res) Vol. 39 Issue 2 Pg. 408-15 ( 2011) ISSN: 1473-2300 [Electronic] England
PMID21672344 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Anticonvulsants
  • Topiramate
  • Fructose
Topics
  • Administration, Oral
  • Aged
  • Anticonvulsants (administration & dosage, therapeutic use)
  • Asian People
  • China
  • Epilepsies, Partial (drug therapy)
  • Female
  • Fructose (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
  • Humans
  • Male
  • Seizures (drug therapy)
  • Topiramate

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