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Determining the efficacy of rasagiline in reducing bradykinesia among Parkinson's disease patients: a review.

AbstractBACKGROUND:
Bradykinesia has a significant impact on the lives of Parkinson's disease (PD) patients. Consequently, treating this symptom is of particular concern for patients and clinicians. A number of studies have documented the efficacy of rasagiline in reducing the severity of PD symptoms.
OBJECTIVE:
To summarize studies that specifically examined the impact of rasagiline on bradykinesia symptoms in PD patients across disease severity.
METHODS:
The EMBASE database was searched for relevant articles published between 2000 and November 2010.
RESULTS:
Three studies were identified that explicitly examined the effect of rasagiline on the bradykinesia subscale of the Unified Parkinson's Disease Rating Scale (UPDRS) motor examination. In each, 1 mg/day rasagiline significantly reduced bradykinesia scores in patients.
CONCLUSION:
As a monotherapy or an adjunctive therapy, rasagiline is an effective drug for reducing the severity of bradykinesia in PD patients.
AuthorsDee E Silver, Philip O Buck
JournalThe International journal of neuroscience (Int J Neurosci) Vol. 121 Issue 9 Pg. 485-9 (Sep 2011) ISSN: 1563-5279 [Electronic] England
PMID21671840 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2011 Informa Healthcare USA, Inc.
Chemical References
  • Indans
  • Neuroprotective Agents
  • rasagiline
Topics
  • Databases, Factual (statistics & numerical data)
  • Humans
  • Hypokinesia (drug therapy, etiology)
  • Indans (therapeutic use)
  • Neuroprotective Agents (therapeutic use)
  • Parkinson Disease (complications)

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