Abstract | OBJECTIVES: To determine the neuropathological load in the living brain of nondemented adults with Down syndrome using positron emission tomography with 2-(1-{6-[(2- fluorine 18-labeled fluoroethyl)methylamino]-2-napthyl}ethylidene) malononitrile ([( 18)F]FDDNP) and to assess the influence of age and cognitive and behavioral functioning. For reference, [( 18)F]FDDNP binding values and patterns were compared with those from patients with Alzheimer disease and cognitively intact control participants. DESIGN: Cross-sectional clinical study. PARTICIPANTS: MAIN OUTCOME MEASURES: Binding of [( 18)F]FDDNP in brain regions of interest, including the parietal, medial temporal, lateral temporal, and frontal lobes and posterior cingulate gyrus, and the average of all regions (global binding). RESULTS: The [( 18)F]FDDNP binding values were higher in all brain regions in the Down syndrome group than in controls. Compared with the Alzheimer disease group, the Down syndrome group had higher [( 18)F]FDDNP binding values in the parietal and frontal regions, whereas binding levels in other regions were comparable. Within the Down syndrome group, age correlated with [( 18)F]FDDNP binding values in all regions except the posterior cingulate, and several measures of behavioral dysfunction showed positive correlations with global, frontal, parietal, and posterior cingulate [( 18)F]FDDNP binding. CONCLUSIONS: Consistent with neuropathological findings from postmortem studies, [( 18)F]FDDNP positron emission tomography shows high binding levels in Down syndrome comparable to Alzheimer disease and greater levels than in members of a control group. The positive associations between [( 18)F]FDDNP binding levels and age as well as behavioral dysfunction in Down syndrome are consistent with the age-related progression of Alzheimer-type neuropathological findings in this population.
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Authors | Linda D Nelson, Prabha Siddarth, Vladimir Kepe, Kevin E Scheibel, S C Huang, Jorge R Barrio, Gary W Small |
Journal | Archives of neurology
(Arch Neurol)
Vol. 68
Issue 6
Pg. 768-74
(Jun 2011)
ISSN: 1538-3687 [Electronic] United States |
PMID | 21670401
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Amyloid beta-Peptides
- tau Proteins
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Topics |
- Adult
- Aged
- Alzheimer Disease
(diagnostic imaging, metabolism, pathology)
- Amyloid beta-Peptides
(metabolism)
- Cross-Sectional Studies
- Down Syndrome
(diagnostic imaging, metabolism, pathology)
- Female
- Humans
- Male
- Middle Aged
- Plaque, Amyloid
(diagnostic imaging, metabolism, pathology)
- Positron-Emission Tomography
(methods)
- Protein Binding
- Young Adult
- tau Proteins
(metabolism)
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