Abstract | OBJECTIVES: METHODS: Women seeking contraception received NuvaRing (n = 300) or a COC (n = 300) for 12 cycles in a randomized, open-label trial. RESULTS: The total number of women with adverse effects did not differ significantly between the 2 groups. Leucorrhea, vaginitis, decreased libido, and ring-related problems were more common with NuvaRing, whereas weight increase, acne, and emotional lability were more common with the COC. Breakthrough bleeding occurred in 11.3% of women receiving NuvaRing and in 14.7% of women receiving the COC; 2.1% and 2.9% of women, respectively, had no withdrawal bleeding. Differences in blood pressure, blood sugar levels, lipid profile, liver enzyme activity, and anticoagulant activity were not statistically significant, with the exception of low-density lipoprotein levels measured at 6 and 12 months, which were significantly lower in the NuvaRing group than in the COC group. CONCLUSIONS:
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Authors | Ahmed M M Mohamed, Wael S M El-Sherbiny, Walaa A I Mostafa |
Journal | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
(Int J Gynaecol Obstet)
Vol. 114
Issue 2
Pg. 145-8
(Aug 2011)
ISSN: 1879-3479 [Electronic] United States |
PMID | 21669426
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Androstenes
- Contraceptives, Oral, Combined
- Contraceptives, Oral, Hormonal
- Drug Combinations
- Lipoproteins, LDL
- NuvaRing
- Ethinyl Estradiol
- Desogestrel
- drospirenone
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Topics |
- Acne Vulgaris
(chemically induced)
- Adolescent
- Adult
- Affective Symptoms
(chemically induced)
- Androstenes
(administration & dosage, adverse effects)
- Contraceptive Devices, Female
(adverse effects)
- Contraceptives, Oral, Combined
(administration & dosage, adverse effects)
- Contraceptives, Oral, Hormonal
(administration & dosage, adverse effects)
- Desogestrel
(administration & dosage, adverse effects, analogs & derivatives)
- Drug Combinations
- Ethinyl Estradiol
(administration & dosage, adverse effects)
- Female
- Humans
- Leukorrhea
(chemically induced)
- Libido
(drug effects)
- Lipoproteins, LDL
(blood)
- Metrorrhagia
(chemically induced)
- Vaginitis
(chemically induced)
- Weight Gain
(drug effects)
- Young Adult
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