99mTc radioimmunoscintigraphy of colorectal cancer.

Abstract

The monoclonal antibody PR1A3 against a normal colonic columnar cell surface antigen has been labelled with 99mTc and used for imaging colorectal cancer. High uptake in undifferentiated cancer is seen. The tumour to mucosa ratio was up to 63:1 and the percentage of the injected activity in the tumour up to 1.7 X 10(-2%)g-1. As 99mTc is continuously available in a Nuclear Medicine Department, on receipt of a request the study may be completed within 24 h enabling radioimmunoscintigraphy to be used routinely in the management of patients with colorectal cancer.

• Authors: M Granowska, S J Mather, K E Britton, S Bentley, P Richman, R K Phillips, J M Northover
• Journal: The British journal of cancer. Supplement (Br J Cancer Suppl) Vol. 10 Pg. 30-3 (Jul 1990) ISSN: 0306-9443 [Print] England
• PMID: 2166551 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Sodium Pertechnetate Tc 99m

Topics

• Adenocarcinoma (diagnostic imaging)
• Antibodies, Monoclonal
• Colorectal Neoplasms (diagnostic imaging)
• Humans
• Radionuclide Imaging
• Sodium Pertechnetate Tc 99m