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Inhibition of simian varicella virus infection of monkeys by 1-(2-deoxy-2- fluoro-1-beta-D-arabinofuranosyl)-5-ethyluracil (FEAU) and synergistic effects of combination with human recombinant interferon-beta.

Abstract
1-(2-Deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-ethyluracil (FEAU) has been shown to be a highly effective inhibitor of Simian varicella virus infection in African green monkeys. Administration of FEAU by either intravenous injection or gavage at doses as low as 1 mg/kg/day prevented the development of rash and reduced viremia. The effective dose could be further reduced to 0.2 mg/kg/day when administered in combination with a sub-effective dose of human recombinant interferon-beta. No evidence of toxicity was seen in monkeys treated for 10 days with FEAU doses of 10 mg/kg/day when they were monitored by hematology and clinical chemistry tests and by clinical observations.
AuthorsK F Soike, T C Chou, J J Fox, K A Watanabe, C A Gloff
JournalAntiviral research (Antiviral Res) Vol. 13 Issue 4 Pg. 165-74 (Apr 1990) ISSN: 0166-3542 [Print] NETHERLANDS
PMID2166466 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antiviral Agents
  • Interferon Type I
  • Recombinant Proteins
  • Arabinofuranosyluracil
  • 1-(2-deoxy-2-fluoroarabinofuranosyl)-5-ethyluracil
  • Uridine
Topics
  • Adenoviridae Infections (prevention & control)
  • Adenoviruses, Simian (drug effects)
  • Animals
  • Antiviral Agents (pharmacology)
  • Arabinofuranosyluracil (administration & dosage, analogs & derivatives, pharmacology)
  • Cercopithecus aethiops
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Humans
  • Injections, Intravenous
  • Interferon Type I (administration & dosage, pharmacology)
  • Recombinant Proteins
  • Uridine (analogs & derivatives)
  • Viremia (drug therapy)

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