Aromatic-turmerone inhibits α-MSH and IBMX-induced melanogenesis by inactivating CREB and MITF signaling pathways.

Abstract

This study investigated the anti-melanogenic effect of aromatic (ar)-turmerone on alpha-melanocyte stimulating hormone (α-MSH) and 3-isobuty-1-methxlzanthine (IBMX)-induced tyrosinase (Tyr), tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) expression in B16F10 melanoma cells. We demonstrated that ar-turmerone inhibits α-MSH and IBMX-induced melanin synthesis and tyrosinase activity. Data also showed that ar-turmerone inhibits the expression of tyrosinase, TRP-1, and TRP-2 in α-MSH- and IBMX-stimulated B16F10 cells. In addition, ar-turmerone exhibits stronger anti-melanogenic effects than curcumin. Furthermore, ar-turmerone strongly inhibited α-MSH- and IBMX-induced microphthalmia-associated transcription factor by suppressing the activity of cyclic adenosine monophosphate (cAMP)-responsive element binding protein in α-MSH-stimulated B16F10 cells. Our data revealed that ar-turmerone is a novel, effective, anti-melanogenic agent that functions by downregulating tyrosinase, Trp-1, and Trp-2 gene expression. Therefore, ar-turmerone may be a useful therapeutic agent for treating hyperpigmentation disorders, such as freckles and melasma, and as a beneficial additive in whitening cosmetics.

• Authors: Sun Young Park, Mei Ling Jin, Young Hun Kim, Younghee Kim, Sang-Joon Lee
• Journal: Archives of dermatological research (Arch Dermatol Res) Vol. 303 Issue 10 Pg. 737-44 (Dec 2011) ISSN: 1432-069X [Electronic] Germany
• PMID: 21660443 (Publication Type: Journal Article)

Chemical References

• Cosmetics
• Hydrocarbons, Aromatic
• Interferon Type I
• Melanins
• Microphthalmia-Associated Transcription Factor
• Pregnancy Proteins
• interferon tau
• alpha-MSH
• Cyclic AMP
• Monophenol Monooxygenase
• Intramolecular Oxidoreductases
• dopachrome isomerase
• Curcumin
• 1-Methyl-3-isobutylxanthine

Topics

• 1-Methyl-3-isobutylxanthine (metabolism)
• Animals
• Cosmetics
• Curcuma
• Curcumin (analogs & derivatives, chemistry, pharmacology)
• Cyclic AMP (genetics, metabolism)
• Enzyme Activation (drug effects)
• Gene Expression Regulation (drug effects)
• Hydrocarbons, Aromatic (chemistry, pharmacology)
• Hyperpigmentation (drug therapy, metabolism)
• Interferon Type I (genetics, metabolism)
• Intramolecular Oxidoreductases (genetics, metabolism)
• Melanins (metabolism)
• Melanoma, Experimental
• Mice
• Microphthalmia-Associated Transcription Factor (genetics, metabolism)
• Monophenol Monooxygenase (genetics, metabolism)
• Pregnancy Proteins (genetics, metabolism)
• alpha-MSH (metabolism)