Abstract | PURPOSE:
Prostate cancer is a worldwide public health problem and its treatment continues to be a therapeutic challenge especially in patients with metastatic androgen-independent cancer. Inflammation is a process that has been involved in the origin of this cancer and its inhibition has been postulated as a prophylactic and therapeutic strategy. The present study evaluated two non-steroidal anti-inflammatory drugs ( meclofenamic acid and mefenamic acid) that have been studied very little in regard to cancer treatment. METHODS: RESULTS: In vitro trials showed that only meclofenamic acid is highly cytotoxic in neoplastic prostate cells. The 5 and 10 mg/kg/day/25 day doses did not cause relevant toxicity in the BALB/c mouse trial, and so both doses were used in the nude-mouse model of cancer trial. This latter trial showed that meclofenamic acid significantly reduces tumor growth, prolongs survival, and is even capable of generating total tumor regression in up to 25% of mice treated at high dose. CONCLUSIONS:
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Authors | Alejandro D Soriano-Hernández, Hector R Galvan-Salazar, Daniel A Montes-Galindo, Alejandrina Rodriguez-Hernandez, Rafael Martinez-Martinez, Jose Guzman-Esquivel, Laura L Valdez-Velazquez, Luz M Baltazar-Rodriguez, Francisco Espinoza-Gómez, Augusto Rojas-Martinez, Rocio Ortiz-Lopez, Rafael Gonzalez-Alvarez, Ivan Delgado-Enciso |
Journal | International urology and nephrology
(Int Urol Nephrol)
Vol. 44
Issue 2
Pg. 471-7
(Apr 2012)
ISSN: 1573-2584 [Electronic] Netherlands |
PMID | 21660425
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androgens
- Anti-Inflammatory Agents, Non-Steroidal
- Meclofenamic Acid
- Prostate-Specific Antigen
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Topics |
- Androgens
(therapeutic use)
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, therapeutic use)
- Disease Progression
- Dose-Response Relationship, Drug
- Humans
- Male
- Meclofenamic Acid
(administration & dosage, therapeutic use)
- Mice
- Mice, Nude
- Neoplasms, Experimental
(drug therapy, metabolism, pathology)
- Prostate-Specific Antigen
(metabolism)
- Prostatic Neoplasms
(drug therapy, metabolism, pathology)
- Treatment Outcome
- Tumor Cells, Cultured
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