[10-Hydroxycamptothecin aerosol treatment inhibits lung metastases in B16F10 melanoma mice models].

Abstract

OBJECTIVE:

To estimate the effect of 10-hydroxycamptothecin (HCPT) to the melanoma lung metastasis mice models and the feasibility of aerosol delivery treatment for lung cancer therapy.

METHOD:

B16F10 melanoma lung metastasis mice models were made, and nodules number, inhibition rate, tumor area, mean nodules diameter and so on were investigated after the aerosol delivery treatment. Spleen index and thymus index were calculated at the end of the experiments. The change of body weight, physiological state and the lung tumor tissue in pathological histology were inspeated.

RESULT:

The total number of tumor lesions, weight of lungs and the area of lung metastasis of aerosol treatment group had significant difference comparing with normal group and control group. Mean nodules diameter had no significant difference comparing with control group. The spleen index of aerosol treatment group was decreased and thymus index was significantly decreased comparing with normal group and control group. During the treatment there are no obvious changes in physiological state. The lung cancer tissue of aerosol delivery treatment group was recovered in pathological histology.

CONCLUSION:

The results suggested that aerosol delivery of HCPT demonstrated powerful antitumor activity and was useful for melanoma lung metastasis by aerosol delivery treatment.

• Authors: Chao Zhang, Wei Hu, Yun Fang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 36 Issue 5 Pg. 618-23 (Mar 2011) ISSN: 1001-5302 [Print] China
• PMID: 21657084 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Camptothecin

Topics

• Administration, Inhalation
• Animals
• Antineoplastic Agents (administration & dosage)
• Camptothecin (administration & dosage)
• Female
• Lung Neoplasms (drug therapy, mortality, pathology)
• Melanoma, Experimental (drug therapy, mortality, pathology, secondary)
• Mice
• Mice, Inbred C57BL
• Weight Loss