Microbial metabolism and biotechnological production of D-allose.

Abstract

D-allose has attracted a great deal of attention in recent years due to its many pharmaceutical activities, which include anti-cancer, anti-tumor, anti-inflammatory, anti-oxidative, anti-hypertensive, cryoprotective, and immunosuppressant activities. D-allose has been produced from D-psicose using D-allose-producing enzymes, including L-rhamnose isomerase, ribose-5-phosphate isomerase, and galactose-6-phosphate isomerase. In this article, the properties, applications, and metabolism of D-allose are described, and the biochemical properties of D-allose-producing enzymes and their D-allose production are reviewed and compared. Moreover, several methods for effective D-allose production are suggested herein.

• Authors: Yu-Ri Lim, Deok-Kun Oh
• Journal: Applied microbiology and biotechnology (Appl Microbiol Biotechnol) Vol. 91 Issue 2 Pg. 229-35 (Jul 2011) ISSN: 1432-0614 [Electronic] Germany
• PMID: 21655980 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• psicose
• Fructose
• allose
• Aldose-Ketose Isomerases
• galactose-6-phosphate isomerase
• L-rhamnose isomerase
• ribosephosphate isomerase
• Glucose

Topics

• Aldose-Ketose Isomerases (metabolism)
• Bacteria (enzymology, metabolism)
• Biotechnology (methods)
• Fructose (metabolism)
• Glucose (biosynthesis)