Patients with familial non-medullary thyroid cancer have an outcome similar to that of patients with sporadic papillary thyroid tumors.

Abstract

OBJECTIVE:

The purpose of this study was to determine whether familial non-medullary thyroid cancer (FNMTC) is more aggressive than sporadic thyroid cancer.

SUBJECTS AND METHODS:

We compared the clinical behavior and outcome of 16 subjects with FNMTC from 7 unrelated kindred with those observed in 160 subjects with sporadic PTC (SPTC) from our database.

RESULTS:

The only different baseline characteristics observed between both groups were: bilateral malignancy, 38% vs. 24%, respectively (p = 0.03), and lymph node metastasis, 56.2% vs. 39%, respectively (p = 0.01). Considering the outcome, in the FNMTC, 9 (56.2%) patients were rendered free of disease, one patient died from thyroid cancer (6%), and 6/16 (37.5%) had persistent disease. In the SPTC Group, 87 (54%) patients were considered free of disease, 11 (7%) died due to PTC, and 62 (38%) had persistent disease (p = ns).

CONCLUSIONS:

Despite the higher incidence of lymph node metastasis in FNMTC patients this situation seemed not to alter the compared outcome.

• Authors: Fabián Pitoia, Graciela Cross, María E Salvai, Erika Abelleira, Hugo Niepomniszcze
• Journal: Arquivos brasileiros de endocrinologia e metabologia (Arq Bras Endocrinol Metabol) Vol. 55 Issue 3 Pg. 219-23 (Apr 2011) ISSN: 1677-9487 [Electronic] Brazil
• PMID: 21655871 (Publication Type: Journal Article)

Chemical References

• Iodine Radioisotopes

Topics

• Adult
• Carcinoma, Papillary (pathology, radiotherapy, secondary)
• Disease Progression
• Female
• Follow-Up Studies
• Humans
• Iodine Radioisotopes (therapeutic use)
• Lymphatic Metastasis
• Male
• Retrospective Studies
• Thyroid Neoplasms (pathology, radiotherapy)