Synthetic routes and biological evaluation of largazole and its analogues as potent histone deacetylase inhibitors.

Abstract

Natural products with interesting biological properties and structural diversity have often served as valuable lead drug candidates for the treatment of various human diseases. Largazole, isolated from the marine cyanobacterium Symploca sp. has exhibited potent inhibitory activity against many cancer cell lines. Besides, it shows remarkable selectivity between transformed and nontransformed cells, which is the main disadvantage of other antitumor natural products such as paclitaxel and actinomycin D. Due to its potential as a potent and selective anticancer drug candidate, a great deal of attention has been focused on largazole and its analogues. It is the aim of this review to highlight synthetic aspects of largazole and its analogues as well as their preliminary structure-activity relationship studies.

• Authors: Shang Li, Hequan Yao, Jinyi Xu, Sheng Jiang
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 16 Issue 6 Pg. 4681-94 (Jun 07 2011) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 21654576 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Depsipeptides
• Histone Deacetylase Inhibitors
• Thiazoles
• largazole
• Histone Deacetylases

Topics

• Depsipeptides (chemical synthesis, chemistry, pharmacology)
• Enzyme Activation (drug effects)
• Histone Deacetylase Inhibitors (chemical synthesis, chemistry, pharmacology)
• Histone Deacetylases (metabolism)
• Humans
• Thiazoles (chemical synthesis, chemistry, pharmacology)