Short- and long-term surgical outcomes in patients undergoing proctocolectomy with ileal pouch-anal anastomosis in the setting of primary sclerosing cholangitis.

Abstract

BACKGROUND:

Primary sclerosing cholangitis occurs in approximately 10% of patients with ulcerative colitis, but studies involving IPAA in patients with cholangitis have been reported in limited numbers.

OBJECTIVE:

This study aimed to examine surgical outcomes in patients with ulcerative colitis and sclerosing cholangitis undergoing total proctocolectomy with IPAA and to identify variables associated with surgical complications.

DESIGN:

This is a retrospective cohort study.

SETTINGS:

This study was conducted at a single tertiary referral institution.

PATIENTS:

Included were all patients with cholangitis and ulcerative colitis who underwent proctocolectomy with IPAA from 1994 to 2005.

MAIN OUTCOME MEASURES:

Perioperative morbidity, long-term pouch function, and pouch survival were the main outcome measures.

RESULTS:

One hundred patients (62 male) were studied. Forty-three percent were on steroids. There was no perioperative mortality, and 51 30-day complications occurred in 39 patients (39%). Median follow-up time was 5.9 years (range, 0.14-16.2 y). Pouch failure occurred in 3 patients (3%). The single variable that predicted 30-day morbidity was previous abdominal surgery (P = .03). Prednisone use, body mass index, age, ASA score, preoperative Model for End Stage Liver Disease score, and year of surgery were not significantly associated with short-term complications.

CONCLUSIONS:

IPAA can be performed safely in the setting of sclerosing cholangitis. The preoperative Model for End-stage Liver Disease Score and the use of preoperative immunosuppressive agents are not associated with an increased risk of complications. The likelihood of long-term pouch survival is excellent.

• Authors: Kellie L Mathis, Luis A Benavente-Chenhalls, Eric J Dozois, Bruce G Wolff, David W Larson
• Journal: Diseases of the colon and rectum (Dis Colon Rectum) Vol. 54 Issue 7 Pg. 787-92 (Jul 2011) ISSN: 1530-0358 [Electronic] United States
• PMID: 21654244 (Publication Type: Comparative Study, Journal Article)

Topics

• Adolescent
• Adult
• Anal Canal (surgery)
• Anastomosis, Surgical (methods)
• Child
• Cholangitis, Sclerosing (complications)
• Colitis, Ulcerative (complications, physiopathology, surgery)
• Colonic Pouches
• Defecation
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Proctocolectomy, Restorative (methods)
• Retrospective Studies
• Time Factors
• Young Adult