Alpha-internexin expression in gliomas: relationship with histological type and 1p, 19q, 10p and 10q status.
Abstract | BACKGROUND: The alpha-internexin (INA) gene encodes an intermediate filament involved in neurogenesis and maps in 10q24.33. A strong INA protein expression has been reported in oligodendroglial tumours and was associated with 1p19q deletion. To assess the relevance of INA immunohistochemistry in glioma typing, this paper studied the relationship between INA expression, histological type, genomic status and patient outcome. METHODS: RESULTS:
Oligodendrogliomas showed strong INA and Olig2 expression, and 1p19q whole loss of heterozygosity (wLOH). Astrocytomas and glioblastomas were characterised by no or weak INA expression, high p53 and nestin expression, 10p10q wLOH, and epidermal growth factor receptor amplification. Most oligoastrocytomas had characteristics of astrocytic tumours. All tumours with strong INA expression retained the 10q chromosome arm and, except for one, had a 1p19q wLOH status. However, despite a strong link between INA expression, 1p19q wLOH and 10q retention, discrepancies were observed in 10% of cases. The presence of INA expression, whether weak or strong, was related to a better prognosis. CONCLUSION: INA expression study can be helpful for glioma typing and prognosis determination in combination with other markers. Nevertheless, INA immunohistochemistry cannot replace the genomic analysis to determine 1p19q and 10p10q status.
|
Authors | Karine Durand, Angélique Guillaudeau, Isabelle Pommepuy, Laura Mesturoux, Alain Chaunavel, Emilie Gadeaud, Marion Porcheron, Jean-Jacques Moreau, François Labrousse |
Journal | Journal of clinical pathology
(J Clin Pathol)
Vol. 64
Issue 9
Pg. 793-801
(Sep 2011)
ISSN: 1472-4146 [Electronic] England |
PMID | 21653654
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Biomarkers, Tumor
- DNA, Neoplasm
- Intermediate Filament Proteins
- alpha-internexin
|
Topics |
- Adult
- Aged
- Biomarkers, Tumor
(genetics, metabolism)
- Brain Neoplasms
(diagnosis, genetics, metabolism)
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 10
- Chromosomes, Human, Pair 19
- DNA, Neoplasm
(analysis)
- Female
- Gene Expression Regulation, Neoplastic
- Glioma
(diagnosis, genetics, metabolism)
- Humans
- Immunohistochemistry
- Intermediate Filament Proteins
(genetics)
- Loss of Heterozygosity
- Male
- Middle Aged
- Prognosis
- Retrospective Studies
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|