[Study of local anaesthetics--Part 194. Evaluation of carbopol hydrogels with lidocaine].

Abstract

The objective of this article is to describe the formulation and evaluation of dermal semisolid drugs--carbopol hydrogels containing the solution of Bukofit, zinc chloride and the local anaesthetic lidocaine. The hydrogels were evaluated after 2, 7, 14 and 28 days after their preparation and stored at the temperature of 5 degrees C +/- 0.2 degrees C. All prepared hydrogels were found to be stable with respect to pH values and rheological parameters. It follows from the found rheological parameters and flow curves that all evaluated hydrogels belong to non-Newtonian thixotropic systems. The extensometric analyses revealed increased deformation values, indicating that the gels can be easily spread out over the mucous membrane which results in the increased ability of the drug to diffuse into it. Based on the results obtained, it can be concluded that the prepared hydrogels have appropriate technological parameters and therefore in the future they may become potential drugs for the treatment of various inflammations in the oral cavity.

• Authors: Zuzana Vitková, Petra Herdová, Jozef Cizmárik, Marián Zabka, Bronislava Brázdovicová, Katarína Bockajová
• Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti (Ceska Slov Farm) Vol. 60 Issue 2 Pg. 79-83 (Apr 2011) ISSN: 1210-7816 [Print] Czech Republic
• Vernacular Title: Stúdium lokálnych anestetík--6ast' 194. Hodnotenie karbopolových hydrogélov s lidokaínom.
• PMID: 21650010 (Publication Type: Journal Article, Review)

Chemical References

• Acrylic Resins
• Anesthetics, Local
• Chlorides
• Drug Carriers
• Hydrogels
• Polyvinyls
• Zinc Compounds
• carboxypolymethylene
• zinc chloride
• Lidocaine

Topics

• Acrylic Resins
• Anesthetics, Local
• Chemistry, Pharmaceutical
• Chlorides
• Drug Carriers
• Hydrogels
• Lidocaine
• Mucous Membrane (metabolism)
• Polyvinyls
• Rheology
• Zinc Compounds