Abstract | BACKGROUND: METHODS: Male Hartley guinea pigs sensitized with OVA were intraperitoneally administered 0.1, 1, or 10 mg/kg of montelukast or 0.1 mg/kg of BAY-u9773 and then challenged with inhaled OVA. Airway reactivity to acetylcholine, inflammatory cells in bronchoalveolar lavage (BAL) fluid, and eosinophil infiltration in airway walls after OVA challenge were evaluated. RESULTS: Pretreatment with 1 or 10 mg/kg, but not 0.1 mg/kg, of montelukast significantly suppressed airway hypersensitivity and eosinophil infiltration into the BAL fluid. Moreover, 0.1 mg/kg of BAY-u9773 significantly suppressed the development of these markers. The suppressive effects of BAY-u9773, although not significantly different, trended toward being greater than those of montelukast. Although all of the doses of montelukast tested and 0.1 mg/kg of BAY-u9773 significantly suppressed eosinophil infiltration in airway walls, the suppressive effect of BAY-u9773 was significantly greater than that of 0.1 mg/kg of montelukast. CONCLUSION: Signaling may contribute to the pathophysiology of asthma via the cysLT1/2 receptor.
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Authors | Masato Muraki, Shu Imbe, Hiroshi Santo, Ryuji Sato, Hiroyuki Sano, Takashi Iwanaga, Yuji Tohda |
Journal | International archives of allergy and immunology
(Int Arch Allergy Immunol)
Vol. 155 Suppl 1
Pg. 90-5
( 2011)
ISSN: 1423-0097 [Electronic] Switzerland |
PMID | 21646802
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 S. Karger AG, Basel. |
Chemical References |
- Acetates
- BAY u9773
- Cyclopropanes
- Leukotriene Antagonists
- Quinolines
- Receptors, Leukotriene
- SRS-A
- Sulfides
- Ovalbumin
- cysteinyl leukotriene receptor 2
- leukotriene D4 receptor
- montelukast
- Acetylcholine
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Topics |
- Acetates
(pharmacology, therapeutic use)
- Acetylcholine
(pharmacology)
- Animals
- Asthma
(chemically induced, drug therapy, immunology, pathology, physiopathology)
- Bronchial Hyperreactivity
(physiopathology, prevention & control)
- Bronchial Provocation Tests
- Bronchoalveolar Lavage Fluid
(cytology)
- Cyclopropanes
- Eosinophils
(pathology)
- Guinea Pigs
- Inflammation
(pathology, prevention & control)
- Leukotriene Antagonists
(pharmacology, therapeutic use)
- Lung
(drug effects, pathology, physiopathology)
- Male
- Ovalbumin
(administration & dosage, immunology)
- Quinolines
(pharmacology, therapeutic use)
- Receptors, Leukotriene
- SRS-A
(analogs & derivatives, pharmacology, therapeutic use)
- Sulfides
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