HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of a cysteinyl leukotriene dual 1/2 receptor antagonist on antigen-induced airway hypersensitivity and airway inflammation in a guinea pig asthma model.

AbstractBACKGROUND:
Little is known about the role of the cysteinyl leukotriene (cysLT) 2 receptor in the pathophysiology of asthma. The aim of this study is to investigate the effects of a cysLT1 receptor antagonist (montelukast) and a dual cysLT1/2 receptor antagonist (BAY-u9773) on airway hypersensitivity and airway inflammation induced by antigen challenge in ovalbumin (OVA)-sensitized guinea pigs.
METHODS:
Male Hartley guinea pigs sensitized with OVA were intraperitoneally administered 0.1, 1, or 10 mg/kg of montelukast or 0.1 mg/kg of BAY-u9773 and then challenged with inhaled OVA. Airway reactivity to acetylcholine, inflammatory cells in bronchoalveolar lavage (BAL) fluid, and eosinophil infiltration in airway walls after OVA challenge were evaluated.
RESULTS:
Pretreatment with 1 or 10 mg/kg, but not 0.1 mg/kg, of montelukast significantly suppressed airway hypersensitivity and eosinophil infiltration into the BAL fluid. Moreover, 0.1 mg/kg of BAY-u9773 significantly suppressed the development of these markers. The suppressive effects of BAY-u9773, although not significantly different, trended toward being greater than those of montelukast. Although all of the doses of montelukast tested and 0.1 mg/kg of BAY-u9773 significantly suppressed eosinophil infiltration in airway walls, the suppressive effect of BAY-u9773 was significantly greater than that of 0.1 mg/kg of montelukast.
CONCLUSION:
Signaling may contribute to the pathophysiology of asthma via the cysLT1/2 receptor.
AuthorsMasato Muraki, Shu Imbe, Hiroshi Santo, Ryuji Sato, Hiroyuki Sano, Takashi Iwanaga, Yuji Tohda
JournalInternational archives of allergy and immunology (Int Arch Allergy Immunol) Vol. 155 Suppl 1 Pg. 90-5 ( 2011) ISSN: 1423-0097 [Electronic] Switzerland
PMID21646802 (Publication Type: Journal Article)
CopyrightCopyright © 2011 S. Karger AG, Basel.
Chemical References
  • Acetates
  • BAY u9773
  • Cyclopropanes
  • Leukotriene Antagonists
  • Quinolines
  • Receptors, Leukotriene
  • SRS-A
  • Sulfides
  • Ovalbumin
  • cysteinyl leukotriene receptor 2
  • leukotriene D4 receptor
  • montelukast
  • Acetylcholine
Topics
  • Acetates (pharmacology, therapeutic use)
  • Acetylcholine (pharmacology)
  • Animals
  • Asthma (chemically induced, drug therapy, immunology, pathology, physiopathology)
  • Bronchial Hyperreactivity (physiopathology, prevention & control)
  • Bronchial Provocation Tests
  • Bronchoalveolar Lavage Fluid (cytology)
  • Cyclopropanes
  • Eosinophils (pathology)
  • Guinea Pigs
  • Inflammation (pathology, prevention & control)
  • Leukotriene Antagonists (pharmacology, therapeutic use)
  • Lung (drug effects, pathology, physiopathology)
  • Male
  • Ovalbumin (administration & dosage, immunology)
  • Quinolines (pharmacology, therapeutic use)
  • Receptors, Leukotriene
  • SRS-A (analogs & derivatives, pharmacology, therapeutic use)
  • Sulfides

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: