Trichosanthin in the treatment of hydatidiform mole. Clinical analysis of 52 cases.

Abstract

During 1972-1986, 44 of 52 patients (84.6%) with hydatidiform mole were treated successfully with trichosanthin. Of these, 38 (73.1%) had complete spontaneous evacuation and 6 (11.5%) incomplete evacuation. The average time for evacuation of hydatidiform mole was 4.5 +/- 1.64 days. The amount of bleeding was less than 100 ml in 33 patients (75%), while that in 2 of the patients with incomplete evacuation was more than 300 ml. Malignant changes occurred in two of the 44 patients (4.5%). The malignant rate was similar to that (4-12.5, P greater than 0.05) of prophylactic chemotherapy. We consider that thrichosanthin is a better approach to the treatment of hydatidiform mole.

• Authors: P X Lu, Y C Jin
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 103 Issue 3 Pg. 183-5 (Mar 1990) ISSN: 0366-6999 [Print] China
• PMID: 2164464 (Publication Type: Journal Article)

Chemical References

• Trichosanthin

Topics

• Female
• Humans
• Hydatidiform Mole (drug therapy)
• Hydatidiform Mole, Invasive (prevention & control)
• Pregnancy
• Trichosanthin (therapeutic use)
• Uterine Neoplasms (drug therapy)