Surgery only for the treatment of patients with stage I (Cassady) Wilms' tumor.

Abstract

A prospective pilot study was undertaken to examine the outcome of patients with Stage I (Cassady) Wilms' tumor treated with nephrectomy only. Eight consecutive patients fulfilling the criteria for Stage I (Cassady) Wilms' tumor (age less than 2 years with unilateral, nonmetastatic, favorable histopathologic type, and tumor weight less than 550 g) underwent nephrectomy with no further therapy. All eight patients were alive and free of disease with a mean follow-up period of 5 years. There was one tumor recurrence that involved a metachronously occurring bilateral tumor. Overall survival (100%) and event-free survival (88%) were comparable with clinical trials in which patients received adjuvant therapy. Patients with Stage I (Cassady) Wilms' tumor can be successfully treated with nephrectomy alone, thereby eliminating the toxicity of adjuvant therapy.

• Authors: E Larsen, A Perez-Atayde, D M Green, A Retik, L A Clavell, S E Sallan
• Journal: Cancer (Cancer) Vol. 66 Issue 2 Pg. 264-6 (Jul 15 1990) ISSN: 0008-543X [Print] United States
• PMID: 2164436 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Topics

• Female
• Humans
• Infant
• Kidney Neoplasms (pathology, surgery)
• Male
• Neoplasm Recurrence, Local (surgery)
• Neoplasm Staging
• Neoplasms, Multiple Primary (surgery)
• Nephrectomy
• Pilot Projects
• Prospective Studies
• Wilms Tumor (pathology, surgery)