Predominant enhancement of apoptosis induced by methyl jasmonate in bladder cancer cells: therapeutic effect of the Antp-conjugated Smac peptide.

Abstract	Methyl jasmonate (MJ) has recently attracted attention as a promising antitumoral compound because of its highly specific proapoptotic properties in a wide range of malignancies. However, the high doses required to achieve a therapeutic benefit have limited its clinical development. Here, we hypothesize that the family of inhibitor of apoptosis proteins (IAPs) may inhibit MJ-mediated apoptosis in cancer cells. We combined MJ with the IAPs inhibitor, the second mitochondria-derived activator of caspases (Smac) peptide to treat bladder cancer cells. The results showed that the combination of MJ and Smac peptide enhanced the apoptosis-inducing effect in a synergistic manner by releasing and activating IAPs-bounding caspase-3. These findings suggest that the inhibition of IAPs could overcome the resistance of cancer cells to MJ.
Authors	Xing-yuan Xiao, Guo-song Jiang, Liang Wang, Lei Lv, Fu-Qing Zeng
Journal	Anti-cancer drugs (Anticancer Drugs) Vol. 22 Issue 9 Pg. 853-63 (Oct 2011) ISSN: 1473-5741 [Electronic] England
PMID	21642838 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Acetates Antennapedia Homeodomain Protein Antineoplastic Agents Antp protein, Drosophila BIRC5 protein, human Cyclopentanes Drosophila Proteins Fluorescent Dyes Inhibitor of Apoptosis Proteins Oligopeptides Oxylipins SMAC peptide Survivin X-Linked Inhibitor of Apoptosis Protein methyl jasmonate Caspase 3 Caspase 9 Bisbenzimidazole
Topics	Acetates (pharmacology) Antennapedia Homeodomain Protein Antineoplastic Agents (metabolism, pharmacology) Apoptosis (drug effects) Bisbenzimidazole Caspase 3 (metabolism) Caspase 9 (metabolism) Cell Survival (drug effects) Cyclopentanes (pharmacology) Drosophila Proteins Drug Evaluation, Preclinical Drug Synergism Fluorescent Dyes HEK293 Cells Humans Inhibitor of Apoptosis Proteins (metabolism) Molecular Targeted Therapy Oligopeptides (metabolism, pharmacology) Oxylipins (pharmacology) Survivin Tumor Cells, Cultured Urinary Bladder Neoplasms (drug therapy, metabolism) X-Linked Inhibitor of Apoptosis Protein (metabolism)

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