Serum apolipoprotein B-48 levels are correlated with carotid intima-media thickness in subjects with normal serum triglyceride levels.

Abstract

BACKGROUND:

Postprandial hyperlipidemia (PPHL) is an independent risk factor for coronary heart disease (CHD) which is based on the accumulation of chylomicrons (CM) and CM remnants containing apolipoprotein B-48 (apoB-48). Since atherosclerotic cardiovascular diseases are frequently observed even in subjects with normal serum triglyceride (TG) level, the correlation between fasting apoB-48 containing lipoproteins and carotid intima-media thickness (IMT) was analyzed in subjects with normal TG levels.

METHODS:

From subjects who took their annual health check at the Osaka Police Hospital (n=245, male), one-hundred and sixty-four male subjects were selected to take part in this study; the excluding factors were: systolic blood pressure ≥ 140 mmHg, intake of antihypertensive or antihyperlipidemic drugs, or age >65 years. The association between biochemical markers and IMT was analyzed and independent predictors of max-IMT were determined by multiple regression analysis in all subjects and in groups N-1 (TG<100mg/dl, n=58), N-2 (100 ≤ TG<150 mg/dl, n=53) and H (150 ≤ TG mg/dl, n=53), respectively.

RESULTS:

Fasting total cholesterol, LDL-cholesterol, HDL-cholesterol, apoB-100 and lnRemL-C (remnant lipoprotein-cholesterol) levels were not correlated with max-IMT, but lnTG and lnapoB-48 were significantly correlated with max-IMT in all subjects. LnapoB-48 and apoB-48/TG ratio were significantly correlated with max-IMT in group N-2. By multiple regression analysis, age and lnapoB-48 were independent variables associated with max-IMT in group N-2.

CONCLUSION:

Serum apoB-48 level might be a good marker for the detection of early atherosclerosis in middle-aged subjects with normal-range levels of blood pressure and TG.

• Authors: Kazuhiro Nakatani, Taizo Sugimoto, Daisaku Masuda, Rieko Okano, Tomoko Oya, Yasumasa Monden, Taiji Yamashita, Ryota Kawase, Hajime Nakaoka, Miwako Inagaki, Miyako Yuasa-Kawase, Kazumi Tsubakio-Yamamoto, Tohru Ohama, Makoto Nishida, Masato Ishigami, Issei Komuro, Shizuya Yamashita
• Journal: Atherosclerosis (Atherosclerosis) Vol. 218 Issue 1 Pg. 226-32 (Sep 2011) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 21641598 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Apolipoprotein B-48
• Biomarkers
• Chylomicrons
• Lipoproteins
• Triglycerides
• Cholesterol

Topics

• Apolipoprotein B-48 (blood)
• Atherosclerosis (blood)
• Biomarkers
• Blood Pressure
• Carotid Intima-Media Thickness
• Cholesterol (blood)
• Chylomicrons (blood)
• Humans
• Lipoproteins (blood)
• Male
• Middle Aged
• Particle Size
• Postprandial Period
• Regression Analysis
• Risk Factors
• Triglycerides (blood)