MicroRNAs and human retroviruses.

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that control a multitude of critical processes in mammalian cells. Increasing evidence has emerged that host miRNAs serve in animal cells to restrict viral infections. In turn, many viruses encode RNA silencing suppressors (RSS) which are employed to moderate the potency of the cell's miRNA selection against viral replication. Some viruses also encode viral miRNAs. In this review, we summarize findings from human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type 1 (HTLV-1) that illustrate examples of host cell miRNAs that target the viruses, of RSS encoded by viruses, and of host cell miRNA profile changes that are seen in infected cells. This article is part of a Special Issue entitled: MicroRNAs in viral gene regulation.

• Authors: Laurent Houzet, Kuan-Teh Jeang
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) 2011 Nov-Dec Vol. 1809 Issue 11-12 Pg. 686-93 ISSN: 0006-3002 [Print] Netherlands
• PMID: 21640212 (Publication Type: Journal Article, Research Support, N.I.H., Intramural, Review)
• Copyright: Published by Elsevier B.V.

Chemical References

• MicroRNAs
• RNA, Viral

Topics

• Gene Expression Regulation, Viral
• HIV-1 (genetics)
• Human T-lymphotropic virus 1 (genetics)
• Humans
• MicroRNAs (genetics, metabolism)
• Models, Genetic
• RNA Interference
• RNA, Viral (genetics, metabolism)
• Retroviridae (genetics)
• Virus Replication