FDG PET/CT in a patient with spontaneous remission of methotrexate-associated lymphoproliferative disorders after interruption of methotrexate.

Abstract

We report a case that fluorodeoxyglucose positron emission tomography (FDG PET)/computed tomography (CT) depicted systemically multiple lesions of methotrexate (MTX)-associated lymphoproliferative disorders. A 70-year-old man receiving MTX for rheumatoid arthritis complained of neck swelling. FDG PET/CT revealed multiple FDG-avid lesions in lymph nodes, lungs, bones, and muscles. Lesions in bones and muscles were not detected on X-CT. Final diagnosis of cervical node was confirmed as MTX-associated lymphoproliferative disorders. FDG PET/CT performed 148 days after discontinuing MTX demonstrated complete remission.

• Authors: Rinnosuke Kuramoto, Kenji Hirata, Toshiki Takei, Nobuhiko Oridate, Seigo Suzuki, Yosuke Yamada, Masahiro Imamura, Nagara Tamaki
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 36 Issue 7 Pg. 582-3 (Jul 2011) ISSN: 1536-0229 [Electronic] United States
• PMID: 21637066 (Publication Type: Case Reports, Journal Article)

Chemical References

• Fluorodeoxyglucose F18
• Methotrexate

Topics

• Aged
• Fluorodeoxyglucose F18
• Humans
• Lymphoproliferative Disorders (chemically induced, diagnostic imaging, pathology)
• Male
• Methotrexate (adverse effects)
• Positron-Emission Tomography
• Remission, Spontaneous
• Tomography, X-Ray Computed