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Effects of canola and corn oil mimetic on Jurkat cells.

AbstractBACKGROUND:
The Western diet is high in omega-6 fatty acids and low in omega-3 fatty acids. Canola oil contains a healthier omega 3 to omega 6 ratio than corn oil. Jurkat T leukemia cells were treated with free fatty acids mixtures in ratios mimicking that found in commercially available canola oil (7% α-linolenic, 30% linoleic, 54% oleic) or corn oil (59% linoleic, 24% oleic) to determine the cell survival or cell death and changes in expression levels of inflammatory cytokines and receptors following oil treatment.
METHODS:
Fatty acid uptake was assessed by gas chromatography. Cell survival and cell death were evaluated by cell cycle analyses, propidium-iodide staining, trypan blue exclusion and phosphatidylserine externalization. mRNA levels of inflammatory cytokines and receptors were assessed by RT-PCR.
RESULTS:
There was a significant difference in the lipid profiles of the cells after treatment. Differential action of the oils on inflammatory molecules, following treatment at non-cytotoxic levels, indicated that canola oil mimetic was anti-inflammatory whereas corn oil mimetic was pro-inflammatory.
SIGNIFICANCE:
These results indicate that use of canola oil in the diet instead of corn oil might be beneficial for diseases promoted by inflammation.
AuthorsGabriela Ion, Kayla Fazio, Juliana A Akinsete, W Elaine Hardman
JournalLipids in health and disease (Lipids Health Dis) Vol. 10 Pg. 90 (Jun 01 2011) ISSN: 1476-511X [Electronic] England
PMID21631947 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Cytokines
  • Fatty Acids, Monounsaturated
  • Inflammation Mediators
  • Lipids
  • Rapeseed Oil
  • Receptors, Cytokine
  • Corn Oil
Topics
  • Apoptosis (drug effects)
  • Cell Cycle (drug effects)
  • Cell Membrane (drug effects, metabolism)
  • Corn Oil (chemistry, pharmacology)
  • Cytokines (metabolism)
  • DNA Fragmentation (drug effects)
  • Fatty Acids, Monounsaturated (chemistry, pharmacology)
  • Gene Expression Regulation, Neoplastic (drug effects)
  • Humans
  • Inflammation Mediators (metabolism)
  • Jurkat Cells
  • Lipids (analysis)
  • Rapeseed Oil
  • Receptors, Cytokine (metabolism)

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