Abstract |
Chronic pancreatitis is a persistent inflammatory disorder characterized by destruction of the pancreatic parenchyma, maldigestion, and chronic pain. Mutations in the chymotrypsin C (CTRC) gene encoding the digestive enzyme CTRC have been shown to increase the risk of chronic pancreatitis in European and Asian populations. Here, we review the biochemical properties and physiological functions of human CTRC, summarize the functional defects associated with CTRC mutations, and discuss mechanistic models that might explain the increased disease risk in carriers.
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Authors | Jiayi Zhou, Miklós Sahin-Tóth |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 26
Issue 8
Pg. 1238-46
(Aug 2011)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 21631589
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Copyright | © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
Chemical References |
- Chymotrypsin
- chymotrypsin C
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Topics |
- Amino Acid Sequence
- Chymotrypsin
(genetics)
- Genetic Predisposition to Disease
- Humans
- Molecular Sequence Data
- Mutation
- Pancreatitis, Chronic
(enzymology, genetics)
- Phenotype
- Risk Assessment
- Risk Factors
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