Extramammary Paget's disease: a novel approach to treatment using a modification of peripheral Mohs micrographic surgery.

Extramammary Paget's disease is a rare intraepithelial adenocarcinoma typified histologically by the presence of Paget cells. Treatment has historically been surgical, with wide excision being the standard of care. However, due to clinically indeterminate margins and diffuse spread, local recurrence rates remain high. Mohs micrographic surgery has been proposed to improve the rate of local recurrence. Application of Mohs technique to treat extramammary Paget's disease can be difficult because of the large size of these lesions. Reported excisions either involved lengthy procedures or peripheral Mohs modification. The peripheral technique does not evaluate the depth of the central lesion, yet prognosis and lymph node involvement are directly related to the degree of vertical invasion. In this study, we discuss our experience with extramammary Paget's disease, along with a novel approach to treatment by using a modification of peripheral Mohs micrographic surgery that incorporates histologic analysis of the central specimen's depth.
AuthorsElizabeth A O'Connor, Patrick C Hettinger, Marcelle Neuburg, William W Dzwierzynski
JournalAnnals of plastic surgery (Ann Plast Surg) Vol. 68 Issue 6 Pg. 616-20 (Jun 2012) ISSN: 1536-3708 [Electronic] United States
PMID21629074 (Publication Type: Journal Article)
  • Aged
  • Female
  • Genital Neoplasms, Male (diagnosis, pathology, surgery)
  • Groin
  • Humans
  • Male
  • Middle Aged
  • Mohs Surgery
  • Paget Disease, Extramammary (diagnosis, pathology, surgery)
  • Scrotum

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: