Treatment of cervical carcinoma with high-dose rate intracavitary brachytherapy: two years follow-up study.

Abstract

AIMS:

This study focused on pelvic recurrence rate and late complications following treatment with high dose rate brachytherapy with a three fractionation scheme.

SETTING AND DESIGN:

This retrospective observational study was conducted from 1st November 2003 to 31st March 2005 at a tertiary care centre.

METHODS AND MATERIALS:

Women were treated with external beam radiotherapy and three fractions of high dose rate brachytherapy, divided into two broad groups IIB+ IIIA and IIIB+IVA. Duration of follow-up was 2 years and main outcome measures were recurrence and rectal and urinary bladder complications. Results were assessed with the Chi square test and P-values using an alpha level of 0.05 for Type I error.

RESULTS:

Of the total of 286 women, 72 (25.4%) developed central-regional recurrence. Overall two year pelvic control rate was 74.6%, with values of 78.1% and 72.8% for stages IIB+ IIIA, IIIB+IVA, respectively. Five women developed distant metastasis and 21.5% suffered low grade rectal complications. After two years the prevalence of bladder complications was only 5.4%.

CONCLUSION:

Using a three fraction scheme, high dose rate brachytherapy is safe and effective in the management of cervix cancer.

• Authors: Diptimay Das, Snehamay Chaudhuri, Asit Ranjan Deb, Ranen Kanti Aich, Subir Gangopadhyay, Amitava Ray
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 12 Issue 3 Pg. 807-10 ( 2011) ISSN: 2476-762X [Electronic] Thailand
• PMID: 21627388 (Publication Type: Journal Article)

Topics

• Adenocarcinoma (complications, radiotherapy, secondary)
• Brachytherapy (adverse effects)
• Carcinoma, Adenosquamous (complications, radiotherapy, secondary)
• Carcinoma, Squamous Cell (complications, radiotherapy, secondary)
• Cross-Sectional Studies
• Female
• Follow-Up Studies
• Humans
• Neoplasm Recurrence, Local (diagnosis, etiology)
• Neoplasm Staging
• Radiation Injuries
• Retrospective Studies
• Survival Rate
• Treatment Outcome
• Urinary Bladder Neoplasms (diagnosis, etiology)
• Uterine Cervical Neoplasms (complications, pathology, radiotherapy)