Pigmented hepatocellular adenoma: report of a case.

Abstract

Hepatocellular adenoma is a rare, benign neoplasm that is related to the use of contraceptives or androgenic-anabolic steroids. A 51-year-old man with no history of steroid use was found to have a liver tumor. Plain computed tomography showed a high-density tumor that was enhanced in the arterial phase, and the enhancement was prolonged in the delayed phase. Magnetic resonance imaging showed that the tumor was hyperintense on in- and opposed-phase T1-weighted gradient recalled echo images and hyperintense on T1-weighted spin echo images. A partial hepatic resection was performed. A histological examination revealed normal hepatocyte-like tumor cells, composed of abundant dark brown granules of Dubin-Johnson-like pigment, which stained positively for Masson-Fontana stain. The tumor was diagnosed to be a very rare hepatocellular adenoma with the deposition of Dubin-Johnson-like pigment.

• Authors: Toshiro Masuda, Toru Beppu, Koei Ikeda, Takatoshi Ishiko, Akira Chikamoto, Hiromitsu Hayashi, Hirohisa Okabe, Ryu Otao, Hiroshi Takamori, Tomohiro Namimoto, Ken-ichi Iyama, Hideo Baba
• Journal: Surgery today (Surg Today) Vol. 41 Issue 6 Pg. 881-3 (Jun 2011) ISSN: 1436-2813 [Electronic] Japan
• PMID: 21626342 (Publication Type: Case Reports, Journal Article)

Chemical References

• Fontana-Masson stain
• Silver Nitrate

Topics

• Adenoma, Liver Cell (pathology, surgery)
• Hepatectomy
• Humans
• Liver Neoplasms (pathology, surgery)
• Male
• Middle Aged
• Pigmentation
• Silver Nitrate