Abstract | BACKGROUND & OBJECTIVES: Fibrous dysplasia (FD) is a rare metabolic bone disease and information available from India is limited to only anecdotal case reports. We describe the clinical profile and therapeutic outcome of 25 patients with FD observed over a period of 14 yr in a tertiary care centre from north India. METHODS: In this retrospective study patients (n = 25) with diagnosis of fibrous dysplasia based on either classical radiological features and/or histological evidence on bone biopsy, were analyzed. Associated endocrinopathies if any, were evaluated. The diagnosis of McCune Albright syndrome (MAS) was considered when fibrous dysplasia was accompanied by either café-au-lait macules and/or endocrinopathies. The clinical presentation, biochemical parameters and imaging were analysed. Seven patients received bisphosphonate therapy. The final outcome and side effects were noted. RESULTS: INTERPRETATION & CONCLUSIONS: This series of FD patients from north India shows the varying presentations of this rare disease. Medical treatment with bisphosphonates appears to be potentially rewarding.
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Authors | Sanjay Kumar Bhadada, Anil Bhansali, Sambit Das, Ramanbir Singh, R Sen, A Agarwal, B R Mittal, Uma Nahar, Pinaki Dutta, Niranjan Khandelwal |
Journal | The Indian journal of medical research
(Indian J Med Res)
Vol. 133
Pg. 504-9
(May 2011)
ISSN: 0971-5916 [Print] India |
PMID | 21623035
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Child
- Diphosphonates
(therapeutic use)
- Female
- Fibrous Dysplasia, Polyostotic
(drug therapy, epidemiology, pathology, surgery)
- Humans
- India
(epidemiology)
- Male
- Middle Aged
- Retrospective Studies
- Treatment Outcome
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