Abstract |
A tag removal-cyclisation sequence is described that is initiated by reduction using a Sm(II) species and completed by a Sm(III) Lewis acid that is formed in an earlier stage. Therefore, the reaction cascade utilises both oxidation states of a samarium reagent in discrete steps and allows access to privileged, pyrrolidinyl- spirooxindole scaffolds and analogues inspired by the anti- cancer natural product spirotryprostatin A.
|
Authors | Susannah C Coote, Seidjolo Quenum, David J Procter |
Journal | Organic & biomolecular chemistry
(Org Biomol Chem)
Vol. 9
Issue 14
Pg. 5104-8
(Jul 21 2011)
ISSN: 1477-0539 [Electronic] England |
PMID | 21617813
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Iodides
- Spiro Compounds
- Samarium
|
Topics |
- Cyclization
- Iodides
(chemistry)
- Molecular Structure
- Samarium
(chemistry)
- Spiro Compounds
(chemical synthesis, chemistry)
- Stereoisomerism
|