Abstract |
T-cell large granular lymphocytic ( LGL) leukemia is a complex diagnosis, requiring persistent clonal expansions of LGLs, and cytopenias. Often the diagnosis is unclear as non-clonal expansions of LGLs commonly occur in reactive conditions. To better understand T-LGL leukemia, we performed a comprehensive clinicopathologic analysis of 85 patients with LGL expansions. Interestingly, distinct CD8+(dim)/CD57+ populations, seen by flow cytometry, were significantly associated with clonal T-LGL leukemia (P < 0.001) as well as neutropenia (median absolute neutrophil count (ANC) 1.45 vs 3.19 × 10(9)/l; P = 0.0017). Furthermore, cases with distinct CD8+(dim)/CD57+ populations and monoclonal T cells had even lower ANCs (median ANC 1.41 × 10(9)/l; P = 0.001) compared with cases without these dual criteria. Additionally, complete or partial loss of CD5 expression was independently associated with clonal T-LGL leukemia (P<0.001) and neutropenia (median ANC 1.41 vs 2.70 × 10(9)/l; P = 0.002). This study describes specific immunophenotypic parameters to better define clonal cases of T-LGL leukemia associated with significant neutropenia.
|
Authors | R S Ohgami, J K Ohgami, I T Pereira, G Gitana, J L Zehnder, D A Arber |
Journal | Leukemia
(Leukemia)
Vol. 25
Issue 9
Pg. 1439-43
(Sep 2011)
ISSN: 1476-5551 [Electronic] England |
PMID | 21617700
(Publication Type: Journal Article)
|
Chemical References |
- Receptors, Antigen, T-Cell, alpha-beta
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Clone Cells
- Female
- Flow Cytometry
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
(genetics, immunology)
- Humans
- Immune System
(immunology)
- Immunophenotyping
- Inflammation
(diagnosis, immunology, metabolism)
- Leukemia, Large Granular Lymphocytic
(diagnosis, immunology, metabolism)
- Male
- Middle Aged
- Neutropenia
(diagnosis, immunology, metabolism)
- Receptors, Antigen, T-Cell, alpha-beta
(genetics, metabolism)
- T-Lymphocytes
(immunology, metabolism)
- Young Adult
|