Optimising absorption of posaconazole.

Abstract

Posaconazole, a triazole antifungal agent with proven efficacy for prophylaxis and treatment of fungal infections, is often limited by poor absorption. We report on five consecutive patients who received posaconazole along with a care bundle intended to increase absorption by addressing gastric pH, co-administration with food, dividing doses and avoiding drug interactions. Each patient yielded multiple robust posaconazole serum concentrations. No patient experienced breakthrough fungal infection while receiving posaconazole. The posaconazole care bundle administered to oncology patients is feasible and may optimise posaconazole absorption.

• Authors: Myke R Green, Joseph E Woolery
• Journal: Mycoses (Mycoses) Vol. 54 Issue 6 Pg. e775-9 (Nov 2011) ISSN: 1439-0507 [Electronic] Germany
• PMID: 21615538 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2011 Blackwell Verlag GmbH.

Chemical References

• Antifungal Agents
• Triazoles
• posaconazole

Topics

• Absorption
• Administration, Oral
• Adult
• Aged
• Antifungal Agents (administration & dosage, pharmacokinetics)
• Female
• Humans
• Male
• Middle Aged
• Mycoses (drug therapy)
• Serum (chemistry)
• Triazoles (administration & dosage, pharmacokinetics)