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Pulpa dentis D30 for acute reversible pulpitis: A prospective cohort study in routine dental practice.

AbstractBACKGROUND:
Pulpa dentis D30 (PD: dental pulp of the calf, prepared in a homeopathic D30 potency) has been used in acute reversible pulpitis for pain relief and to avoid or postpone invasive dental treatment.
PRIMARY STUDY OBJECTIVE:
To study short-term clinical outcomes of PD therapy for acute reversible pulpitis in routine dental practice.
METHODS/DESIGN:
Prospective, observational, open-label, single-arm cohort study.
SETTING:
Eleven dental primary care practices in Germany.
PARTICIPANTS AND INTERVENTION:
Thirty-two patients starting monotherapy with PD for acute reversible pulpitis without visible or radiological abnormalities. PD was applied as 1-mL submucous injections into the mucobuccal fold, repeated daily as needed.
PRIMARY OUTCOME MEASURES:
Avoidance of invasive dental treatment (pulp capping, root canal therapy, tooth extraction) and remission of pain, measured on a 0-10 point scale (partial remission: reduction by > or =3 points; complete remission: reduction from > or =4 points to 0-1 points) during the 10-day follow-up period.
RESULTS:
Median pain duration was 14.0 days. The patients received a median of two PD applications (range 1-7). A total of 81% (n=26/32) of patients did not require invasive dental treatment, and 19% (n= 6) had root canal therapy. Remission status was evaluable in 24 patients. Of these, 63% (n = 15/24) achieved pain remission, 58% (n = 14) remitted without invasive dental treatment (complete remission: n=12, partial remission: n=2), and 29% (n= 7) had a close temporal relationship between PD and remission (ratio "time to remission after first PD application vs pain duration prior to first PD application" <1:10).
CONCLUSION:
In this study of PD for acute reversible pulpitis, 58% of evaluable patients achieved pain remission without invasive dental treatment. The open-label pre-post design does not allow for conclusions about comparative effectiveness. However, more than one-fourth of evaluable patients remitted with a close temporal relationship between the first PD application and pain remission, suggesting a causal relationship between therapy and remission.
AuthorsHarald Johan Hamre, Inge Mittag, Anja Glockmann, Helmut Kiene, Wilfried Tröger
JournalAlternative therapies in health and medicine (Altern Ther Health Med) 2011 Jan-Feb Vol. 17 Issue 1 Pg. 16-21 ISSN: 1078-6791 [Print] United States
PMID21614940 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Topics
  • Acute Disease
  • Adult
  • Animals
  • Cattle
  • Cohort Studies
  • Dental Care (methods)
  • Dental Pulp
  • Female
  • Homeopathy (methods)
  • Humans
  • Male
  • Middle Aged
  • Pain (etiology)
  • Pain Management
  • Pain Measurement
  • Prospective Studies
  • Pulpitis (complications, therapy)
  • Single-Blind Method
  • Treatment Outcome
  • Young Adult

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