Gabapentin-induced sexual dysfunction.

Abstract

Sexual dysfunction is a key adverse effect leading to medication noncompliance. Psychotropic drugs associated with sexual dysfunction include antiepileptic drugs, antidepressants, and antipsychotics. Gabapentin, frequently used off-label to treat psychiatric and pain disorders, has previously been reported to cause sexual dysfunction at a minimum total daily dose of 900 mg. This report addresses dose-dependent gabapentin-induced sexual dysfunction reaching total sexual dysfunction (loss of libido, anejaculation, anorgasmia, and impotence) at a total daily dose of only 300 mg.

• Authors: Kenneth R Kaufman, Peter J Struck
• Journal: Epilepsy & behavior : E&B (Epilepsy Behav) Vol. 21 Issue 3 Pg. 324-6 (Jul 2011) ISSN: 1525-5069 [Electronic] United States
• PMID: 21612983 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Amines
• Anti-Anxiety Agents
• Cyclohexanecarboxylic Acids
• gamma-Aminobutyric Acid
• Gabapentin

Topics

• Adult
• Amines (adverse effects)
• Anti-Anxiety Agents (adverse effects)
• Cyclohexanecarboxylic Acids (adverse effects)
• Depression (drug therapy)
• Gabapentin
• Humans
• Male
• Sexual Dysfunction, Physiological (chemically induced)
• gamma-Aminobutyric Acid (adverse effects)