In vitro and in vivo evaluation of sanguinarine liposomes prepared by a remote loading method with three different ammonium salts.

Abstract	Sanguinarine liposomes were prepared by a remote loading method using three different ammonium salts. A series of studies, including in vitro release, in vitro and in vivo anti-tumor effects and pharmacokinetics in rats, were conducted. The three liposomes showed pH-sensitive release characteristics in vitro, but there were obvious variations in their release profiles. Among the three liposomes, the liposomes made using ammonium citrate and phosphate possessed better anti-tumor activity in vitro and in vivo, compared with the liposome using ammonium sulfate. Pharmacokinetics test results in rats indicated that sanguinarine liposomes have notably elevated AUC (P<0.05) and markedly lower CL (P<0.05) compared with the solution, but there were no obvious differences between the three liposomes. The present study may be useful for better understanding and better choice of a suitable ammonium salt for the remote loading method.
Authors	X Ke, J H Bei, Y Zhang, J Li
Journal	Die Pharmazie (Pharmazie) Vol. 66 Issue 4 Pg. 258-63 (Apr 2011) ISSN: 0031-7144 [Print] Germany
PMID	21612152 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents, Phytogenic Benzophenanthridines Indicators and Reagents Isoquinolines Liposomes Quaternary Ammonium Compounds Tetrazolium Salts Thiazoles sanguinarine thiazolyl blue
Topics	Animals Antineoplastic Agents, Phytogenic (administration & dosage, chemistry, pharmacokinetics) Benzophenanthridines (administration & dosage, chemistry, pharmacokinetics) Cell Line, Tumor Chromatography, High Pressure Liquid Drug Compounding Drug Screening Assays, Antitumor Indicators and Reagents Isoquinolines (administration & dosage, chemistry, pharmacokinetics) Liposomes (chemistry) Male Microscopy, Electron, Transmission Particle Size Quaternary Ammonium Compounds (chemistry) Rats Rats, Wistar Tetrazolium Salts Thiazoles

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