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Chemical inhibitors: the challenge of finding the right target.

Abstract
A paper in this issue of Chemistry & Biology shows that the diaryl oxazole compound UA62784 that targets pancreatic cancer cells interacts with tubulin near the colchicine binding site (Tcherniuk et al., 2011). These findings differ from previous observations, highlighting the challenges of identifying the biological target for chemical inhibitors.
AuthorsDavid Calligaris, Daniel Lafitte
JournalChemistry & biology (Chem Biol) Vol. 18 Issue 5 Pg. 555-7 (May 27 2011) ISSN: 1879-1301 [Electronic] United States
PMID21609834 (Publication Type: Comment, Journal Article)
CopyrightCopyright © 2011 Elsevier Ltd. All rights reserved.

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