HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Histological chorioamnionitis - implication for bacterial colonization, laboratory markers of infection, and early onset sepsis in very-low-birth-weight neonates.

AbstractOBJECTIVE:
The objective of this study was to evaluate the relationship between histological chorioamnionitis and laboratory markers of infection and congenital sepsis in very-low-birth-weight (VLBW) premature neonates.
METHOD:
This study is a retrospective review of laboratory results of VLBW neonates with birth weight less than 1500 g in our neonatal intensive care unit (NICU) in the last 5 years.
RESULTS:
Ninety-nine VLBW neonates had histological chorioamnionitis, and 50 of them further had funisitis. One hundred and sixty-two VLBW neonates did not have chorioamnionitis. The chorioamnionitis group was more likely than the 'no chorioamnionitis' group to have raised C-reactive proteins (23% versus 9.9%; p = 0.006) and neutrophilia (41% versus 4.3%; p < 0.001). White blood cells were more likely to be present in gastric lavage of the former group than the latter group (70% versus 50%; p = 0.002). Ear swab and gastric lavage were more likely to yield positive growth of micro-organisms from the former group than the latter group (34% versus 9.9% and 22% versus 2.7%; p < 0.001 and p < 0.001, respectively). Congenital sepsis proven by positive blood culture was also more likely to occur (3% versus 0%; p = 0.027). Presence of funisitis further increased the likelihood of the above abnormal laboratory results.
CONCLUSIONS:
Histological chorioamnionitis increases the likelihood of having markers of infection, bacterial colonization, and congenital sepsis. Only 3% of histological chorioamnionitis resulted in congenital sepsis confirmed by blood culture.
AuthorsShing Yan Robert Lee, Chi Wai Leung
JournalThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (J Matern Fetal Neonatal Med) Vol. 25 Issue 4 Pg. 364-8 (Apr 2012) ISSN: 1476-4954 [Electronic] England
PMID21609204 (Publication Type: Evaluation Study, Journal Article)
Chemical References
  • Biomarkers
Topics
  • Age of Onset
  • Bacterial Physiological Phenomena
  • Biomarkers (analysis)
  • Chorioamnionitis (diagnosis, microbiology, pathology)
  • Clinical Laboratory Techniques (methods)
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases (diagnosis, microbiology)
  • Infant, Premature, Diseases (diagnosis, microbiology)
  • Infant, Very Low Birth Weight (immunology, physiology)
  • Intensive Care Units, Neonatal (statistics & numerical data)
  • Pregnancy
  • Pregnancy Complications, Infectious (diagnosis, microbiology, pathology)
  • Retrospective Studies
  • Sepsis (congenital, diagnosis, epidemiology, microbiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: