Anoctamins.

Abstract

Endogenous Ca(2+)-activated Cl(-) channels (CaCC) demonstrate biophysical and pharmacological properties that are well represented in cells overexpressing anoctamin 1 (Ano 1, TMEM16A), a protein that has been identified recently as CaCC. Proteins of the anoctamin family (anoctamin 1-10, TMEM16A-K) are widely expressed. The number of reports demonstrating their physiological and clinical relevance is quickly rising. Anoctamins gain additional interest through their potential role in cell volume regulation and malignancy. Available data suggest that Ano 1 forms stable dimers and probably liaise with accessory proteins such as calmodulin or other anoctamins. In order to understand how anoctamins produce Ca(2+)-activated Cl(-) currents, it will be necessary to obtain better insight into their molecular structure, interactions with partner proteins, and mode of activation.

• Authors: Karl Kunzelmann, Yuemin Tian, Joana Raquel Martins, Diana Faria, Patthara Kongsuphol, Jiraporn Ousingsawat, Frank Thevenod, Eleni Roussa, Jason Rock, Rainer Schreiber
• Journal: Pflugers Archiv : European journal of physiology (Pflugers Arch) Vol. 462 Issue 2 Pg. 195-208 (Aug 2011) ISSN: 1432-2013 [Electronic] Germany
• PMID: 21607626 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Chloride Channels
• Membrane Proteins
• Receptors, Cell Surface
• Calcium

Topics

• Animals
• Calcium (metabolism)
• Chloride Channels (chemistry, genetics, metabolism)
• Humans
• Membrane Proteins (metabolism)
• Models, Molecular
• Receptors, Cell Surface (metabolism)