[Adrenal pheochromocytoma associated with "tako-tsubo" syndrome].

Abstract

"Tako-tsubo" cardiomyopathy is a condition characterized by a transitory left ventricular asinergia, induced by physical and emotional stress. In literature there are few cases of association between cardiomyopathy and pheochromocytoma. We described a case of a 72 year-old woman admitted in Emergency Room for chest pain associated with high blood pressure: the ECG showed non-ST elevation in leads III, AVF and V1. An echocardiogram showed global reduction in contractility (EF 40%) with apical akinesia. The coronary angiography showed coronary without stenosis while left ventriculography showed an average apical akinesia of the anterior wall with enhanced contractility of basal segments. Subsequently, the patient continued to present episodes of tremors associated with high blood pressure and therefore was made the determination of urinary metanephrines and urinary vanilmandelic acid that were both high. A subsequent abdomen MRI showed a 32 mm left adrenal lesion with arterial phase impregnation. The diagnosis of left adrenal pheochromocytoma was made and the tumor, after appropriate preoperative pharmacological preparation with α-blockers, was removed surgically. In conclusion, the unexplained transitory left ventricular asinergia alert the clinician of an underlying disorder, such as pheochromocytoma, the early detection of which is crucial to the prognosis.

• Authors: Laura Zinnamosca, Luigi Petramala, Dario Cotesta, Maria Luisa Lefons, Cristiano Marinelli, Piero Chirletti, Cesare Greco, Claudio Letizia
• Journal: Recenti progressi in medicina (Recenti Prog Med) Vol. 102 Issue 5 Pg. 202-6 (May 2011) ISSN: 0034-1193 [Print] Italy
• Vernacular Title: Un caso di feocromocitoma surrenalico manifestatosi con un quadro di cardiomiopatia tipo "tako-tsubo".
• PMID: 21607004 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Biomarkers
• Metanephrine
• Vanilmandelic Acid

Topics

• Adrenal Gland Neoplasms (complications, diagnosis, surgery, urine)
• Adrenalectomy
• Aged
• Biomarkers (urine)
• Chest Pain (etiology)
• Coronary Angiography
• Diagnosis, Differential
• Electrocardiography
• Female
• Humans
• Hypertension (etiology)
• Metanephrine (urine)
• Pheochromocytoma (complications, diagnosis, surgery, urine)
• Takotsubo Cardiomyopathy (complications, diagnosis)
• Treatment Outcome
• Vanilmandelic Acid (urine)