Abstract | OBJECTIVE: METHODS: We conducted a population-based study of 8763 individuals, of whom 1417 developed a first cancer during 15years of follow-up, and a meta-analysis. We stratified absolute 10-year risk of cancer by smoking status, an important risk factor. RESULTS: In women, transferrin saturation above 60% versus below 50% was associated with a hazard ratio of 3.6 (95% confidence interval (CI): 2.0-6.5; P<0.001) for any cancer; risk of liver cancer was increased in both women and men. In women, the corresponding absolute 10-year risk of any cancer was 34% and 30% in smokers and nonsmokers, respectively. In men, haemochromatosis genotype C282Y/C282Y versus wild type/wild type was associated with a hazard ratio of 3.7 (95% CI: 1.2-12; P=0.01) for any cancer, with a similar trend in women. In men, the corresponding absolute 10-year risk of cancer was 39% and 27% in smokers and nonsmokers, respectively. Other haemochromatosis genotypes were not associated with increased risk of cancer in women or men. From the meta-analysis, the odds ratio of any cancer for transferrin saturation ≥60% versus a reference group was 1.5 (95% CI: 1.2-1.8) for women and men combined. CONCLUSIONS: We have demonstrated that elevated transferrin saturation levels in women and haemochromatosis genotype C282Y/C282Y in men are associated with increased risk of cancer. Thus, our results support the implementation of cancer screening programmes in patients with iron overload or with C282Y/C282Y.
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Authors | C Ellervik, A Tybjaerg-Hansen, B G Nordestgaard |
Journal | Journal of internal medicine
(J Intern Med)
Vol. 271
Issue 1
Pg. 51-63
(Jan 2012)
ISSN: 1365-2796 [Electronic] England |
PMID | 21605201
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 The Association for the Publication of the Journal of Internal Medicine. |
Chemical References |
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Topics |
- Adult
- Aged
- Female
- Genotype
- Hemochromatosis
(blood, genetics)
- Humans
- Male
- Middle Aged
- Neoplasms
(blood, epidemiology, genetics)
- Prospective Studies
- Risk Factors
- Transferrin
(analysis)
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