[Experimental study on anti-influenza virus infection with yinqiao-decoction by orthogonal design].

Abstract

OBJECTIVE:

To investigate composition principle of Yinqiao-decoction through experiment of anti-influenza.

METHODS:

The effects of different compositions of Yinqiao-decoction on the index of hemagglutinin titre of virus in the lung tissue of mice infected with virus from nose were investigated by orthogonal design.

RESULTS:

According to the hemagglutinin titre of virus in the lung tissue of mice, the necessary effective drugs of Yinqiao-decoction are forsythia suspense, flos lonicerae, fructus arctii, schizonepeta tenuifolia, folium phyllostach lophatheri, glycyrrhiza uralensis, platycodon grandiflorum and mentha haplocalyx, and semen sojae preparatum isn't necessary. There is interaction between forsythia suspense and flos lonicerae, forsythia suspense and fructus arctii, forsythia suspense and schizonepeta tenuifolia, fructus arctii and mentha haplocalyx, schizonepeta tenuifolia and platycodon grandiflorum.

CONCLUSION:

The optimal combination of Yinqiao-decoction is flos lonicerae, forsythia suspense, fructus arctii, folium phyllostach lophatheri, glycyrrhiza uralensis, mentha haplocalyx of the second level and schizonepeta tenuifolia, platycodon grandiflorum, semen sojae preparatum of the first level.

• Authors: Zhen-Qi Wu, Guang-Hua Liu, Li-Juan Yan, Chun-Hong Nan, Zhi-Jun Yue, Xue-Feng Wang
• Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi) Vol. 24 Issue 6 Pg. 427-9 (Dec 2010) ISSN: 1003-9279 [Print] China
• PMID: 21604566 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Infective Agents
• Drugs, Chinese Herbal
• yinqiao

Topics

• Animals
• Anti-Infective Agents (pharmacology)
• Drugs, Chinese Herbal (pharmacology)
• Female
• Lung (virology)
• Male
• Mice
• Orthomyxoviridae (metabolism)
• Orthomyxoviridae Infections (drug therapy, virology)