Abstract | BACKGROUND: METHODS: In all, 98 consecutive adult patients (age 25-55 years) with CD (n = 70) and UC (n = 28) were enrolled and assessed at three timepoints over 1 year. RESULTS: There were no significant differences in levels of homocysteine, B vitamins, or dietary intake by disease type, disease activity, or across visits. 13% of all inflammatory bowel disease (IBD) patients had elevated homocysteine at least once during the study. Nine patients with CD had fluctuating homocysteine levels during the study but these were inconsistent, ranging from within normal range to elevated levels in any individual. Six of these nine patients were persistently in remission. 30% of all IBD patients had vitamin B6 deficiency, 11% had vitamin B12 deficiency, and one patient (CD) had folate deficiency. All vitamins showed a significant correlation between intake and serum levels (B6; r = 0.46, P < 0.001, B12; r = 0.42, P < 0.001, and folate; r = 0.26, P = 0.008). There was an inverse relationship between serum homocysteine in the blood and serum vitamin B12 (r = -0.241, P = 0.017). CONCLUSIONS:
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Authors | Kathy Vagianos, Charles N Bernstein |
Journal | Inflammatory bowel diseases
(Inflamm Bowel Dis)
Vol. 18
Issue 4
Pg. 718-24
(Apr 2012)
ISSN: 1536-4844 [Electronic] England |
PMID | 21604334
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Crohn's & Colitis Foundation of America, Inc. |
Chemical References |
- Homocysteine
- Vitamin B Complex
- Folic Acid
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Topics |
- Adult
- Dietary Supplements
- Female
- Folic Acid
(blood)
- Folic Acid Deficiency
(blood)
- Homocysteine
(blood)
- Humans
- Inflammatory Bowel Diseases
(blood)
- Male
- Middle Aged
- Nutritional Status
- Prospective Studies
- Severity of Illness Index
- Vitamin B 12 Deficiency
(blood)
- Vitamin B 6 Deficiency
(blood)
- Vitamin B Complex
(blood)
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