Effects of allitridin on acute and chronic mouse cytomegalovirus infection.

Abstract

This study investigated the effects of allitridin on acute and chronic mouse cytomegalovirus (MCMV) infections in vivo. The results demonstrated that allitridin reduced the titers of MCMV in salivary glands, and reductions in viral loads were confirmed by determining viral DNA and RNA levels in susceptible organs during the acute infection phase. Although allitridin did not eliminate MCMV, treatment reduced viral levels and facilitated healing of pathologic lesions in organs, particularly during the chronic infection phase. The results presented in this report suggest that allitridin could act as an effective agent against MCMV infections in vivo.

• Authors: Xing-lou Liu, Hui Wang, Ya-nan Li, Hai-xia Ge, Sai-nan Shu, Feng Fang
• Journal: Archives of virology (Arch Virol) Vol. 156 Issue 10 Pg. 1841-6 (Oct 2011) ISSN: 1432-8798 [Electronic] Austria
• PMID: 21604182 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Allyl Compounds
• Antiviral Agents
• Sulfides
• diallyl trisulfide

Topics

• Acute Disease (therapy)
• Allyl Compounds (pharmacology)
• Animals
• Antiviral Agents (pharmacology)
• Chronic Disease (therapy)
• Cytomegalovirus (drug effects, physiology)
• Cytomegalovirus Infections (drug therapy, virology)
• Disease Models, Animal
• Female
• Herpesviridae Infections (drug therapy, virology)
• Humans
• Mice
• Mice, Inbred BALB C
• Muromegalovirus (drug effects, physiology)
• Salivary Glands (virology)
• Sulfides (pharmacology)
• Viral Load (drug effects)